Cheap Daklinza (Daclatasvir) Online
Daklinza (Daclatasvir)
Daklinza (daclatasvir) is a medication used to treat chronic hepatitis C virus (HCV) genotype 1 and genotype 3 infections.Affordability and accessibility are fundamental factors when it comes to ensuring effective healthcare for individuals living with chronic conditions. In the case of hepatitis C, a viral infection affecting the liver, access to affordable and high-quality medications is crucial for managing the disease and improving quality of life. Daklinza (Daclatasvir), a potent antiviral agent, has revolutionized the treatment of hepatitis C, offering hope to millions around the world.
However, the high cost of brand-name Daklinza 60 mg tablet can create significant financial barriers for patients in need of this life-changing medication. Thankfully, the rise of online pharmacies has opened up new avenues for affordable healthcare, enabling individuals to purchase cheap generic Daklinza (Daclatasvir) online.
What is Daklinza (Daclatasvir)?
Daklinza (Daclatasvir) is a prescription medication used for the treatment of chronic hepatitis C, a viral infection that affects the liver. It is classified as a direct-acting antiviral (DAA), designed to target and inhibit the replication of the hepatitis C virus (HCV) in the body.
The drug is often prescribed in combination with other antiviral medications as part of a comprehensive treatment regimen. The specific combination therapy and duration may vary depending on factors such as the HCV genotype, liver condition, and individual patient characteristics.
The active ingredient in the medicine, Daclatasvir, works by blocking a protein called NS5A, which is essential for the replication of the hepatitis C virus. By inhibiting NS5A, the drug helps to prevent the virus from multiplying and spreading within the body.
Daklinza 60 mg has shown efficacy across different HCV genotypes, including genotype 1, 2, 3, and 4. The goal of treatment with the drug is to achieve sustained virologic response (SVR), which means the virus becomes undetectable in the blood and indicates a successful cure for hepatitis C.
It is important to note that these tablets should only be used under the guidance and prescription of a healthcare professional experienced in the treatment of hepatitis C. They will determine the appropriate dosage, treatment duration, and combination therapy based on the individual’s specific circumstances.
How it works
Daklinza (Daclatasvir) exerts its mechanism of action by specifically targeting and inhibiting a viral protein known as NS5A, which is essential for the replication and assembly of the hepatitis C virus (HCV).
NS5A plays a crucial role in the HCV life cycle, regulating viral replication, assembly, and release. The medicine binds to NS5A and interferes with its function, disrupting the virus’s ability to replicate its genetic material and produce new virus particles.
By inhibiting NS5A, the drug disrupts the replication process of the hepatitis C virus, leading to a reduction in viral load within the body. This reduction in viral load helps to slow down the progression of the infection and allows the body’s immune system to better control the virus.
Daklinza 60 mg tablet is often used in combination with other antiviral medications, such as sofosbuvir, to form a comprehensive treatment approach. The combination therapy works synergistically to attack the virus from multiple angles, targeting different stages of the viral life cycle and enhancing treatment efficacy.
The ultimate goal of the treatment is to achieve sustained virologic response (SVR), which indicates that the virus becomes undetectable in the blood for at least 12 weeks after completing treatment. SVR is considered a marker of a successful cure for chronic hepatitis C.
Indications for use
Here’s a table specifying the target populations for Daklinza (Daclatasvir):
| Target Population | Description |
| Treatment-Naive Patients | Individuals who are newly diagnosed with chronic hepatitis C and have not received any prior treatment for the infection. |
| Treatment-Experienced Patients | Individuals who have previously undergone treatment for chronic hepatitis C but did not achieve a sustained virologic response (SVR). |
| HCV Genotypes | The drug is indicated for the treatment of chronic hepatitis C infection caused by the following genotypes: |
| – Genotype 1a | |
| – Genotype 1b | |
| – Genotype 2 | |
| – Genotype 3 | |
| – Genotype 4 | |
| Compensated Cirrhosis | Individuals with compensated cirrhosis, a stage of liver disease characterized by liver damage but still maintaining adequate function. |
| HIV Coinfection | Suitable for individuals coinfected with both chronic hepatitis C and human immunodeficiency virus (HIV). |
Please note that this table serves as a general guide and is not exhaustive. The appropriateness of this drug for specific individuals should be determined by a healthcare professional experienced in the treatment of hepatitis C, taking into account factors such as HCV genotype, liver condition, patient characteristics, and potential drug interactions.
Dosage
Determining the appropriate Daklinza (daclatasvir) dosage, a medication utilized in the treatment of hepatitis C, is dependent on several individual factors, including age, gender, weight, and liver and kidney function, as well as the genotype of the hepatitis C virus present in the patient.
For adult patients, encompassing senior citizens and females, the typical dosage of Daklinza is generally 60 mg, administered once per day. However, adjustments may be necessary based on how the patient responds to the treatment and other health issues, like impaired kidney or liver function.
In the case of children: The use of this medicine is not advised for pediatric patients who are under 18 years old.
Always seek advice from a healthcare professional who can evaluate your unique health situation and prescribe the most suitable dosage and treatment plan.
The drug should also be used in conjunction with other antiviral medications for hepatitis C virus (HCV).
Instructions for use
| Step | Instruction | Detailed Explanation |
| 1 | Take the prescribed dosage. | The drug is typically prescribed as a 60 mg oral dose daily. Your healthcare provider may vary this depending on your individual health condition, your response to treatment, and other medical considerations. |
| 2 | Daklinza can be ingested with or without meals. | Consistency in the medication’s levels in your body can be maintained by taking it with meals, but if necessary, the tablet can be taken on an empty stomach. |
| 3 | The tablet should not be chewed, crushed, or broken. | To ensure the drug is effectively absorbed, the tablet should be swallowed whole. Changing the tablet’s form can impact the efficacy of the drug. |
| 4 | Address missed doses appropriately. | If a dose is missed, take it as soon as you recall. But, if the time for the next dose is near, bypass the missed dose and stick to your regular schedule. Doubling up on doses is not recommended. |
| 5 | Daklinza should be taken with other antiviral medications. | Daclatasvir 60 mg is usually administered in conjunction with other antiviral drugs for Hepatitis C treatment. Adhere to your healthcare provider’s guidance for all prescribed drugs to ensure successful treatment. |
| 6 | Complete the entire treatment regimen. | The prescribed treatment period usually spans between 12 to 24 weeks, as guided by your healthcare provider. Even if your symptoms improve, it’s important to continue taking the tablets for the complete duration to thoroughly eliminate the virus. |
| 7 | Daklinza should be stored appropriately. | The drug should be stored at room temperature, shielded from light and moisture. Avoid bathroom storage and make sure it’s inaccessible to children and pets to prevent unintended ingestion or misuse. |
| 8 | Be vigilant for potential side effects. | Daclatasvir side effects may include fatigue, headaches, nausea, or insomnia. If severe side effects arise or if side effects persist, promptly consult with your healthcare provider. |
Keep in mind that this table offers general guidance and doesn’t substitute for professional medical advice. Always follow your healthcare provider’s personalized instructions.
Side effects
Here is a list of the most frequently reported:
- Fatigue
- Headache
- Nausea
- Insomnia
- Dizziness
- Shortness of Breath
- Irritability
- Diarrhea
- Muscle Pain
- Rash
- Hair Loss
- Decreased Appetite
- Dry Mouth
- Cough
- Stomach Pain
Remember, while these side effects are commonly reported, they do not occur in all patients. Some patients may experience side effects not listed here. Always communicate with your healthcare provider if you experience these or any other side effects while taking Daklinza 60 mg.
Contraindications for use
Individuals with a history of allergic reactions to daclatasvir or any other constituent of Daklinza, characterized by signs like hives, itchiness, swelling, severe dizziness, or trouble breathing, should refrain from using this medication. The drug may not be the right treatment choice for patients with severe liver disease as the drug’s impact on these patients might be uncertain and potentially detrimental to their health condition.
Certain medications such as rifampin, St. John’s wort, carbamazepine, phenytoin, and phenobarbital can significantly lessen Daclatasvir’s effectiveness by decreasing its concentration in the blood, promoting the likelihood of drug resistance. Also, taking these tablets alongside potent inhibitors of the enzyme CYP3A4 can elevate Daclatasvir’s levels in the blood, potentially raising the probability of side effects.
The potential harm Daclatasvir could cause to an unborn baby is unclear, so it’s generally not recommended for pregnant women unless the foreseeable health benefits supersede the possible risks. Furthermore, as it’s uncertain if Daclatasvir can be passed on via breast milk, nursing mothers are advised to exercise caution.
For patients co-infected with HIV-1, Daklinza 60 mg tablet shouldn’t be used unless they are concurrently receiving appropriate antiretroviral therapy, as there’s a risk of a surge in HIV-1 virus levels. Lastly, those with rare inherited conditions such as intolerance to galactose, deficiency in Lapp lactase, or an inability to absorb glucose-galactose should not take this medication.
Remember that contraindications can vary based on individual circumstances. This summary should be used as a guideline, and medical advice should always be sought from a healthcare provider before initiating a new medication.
Precautions and warnings
- Pre-existing Liver Conditions: Patients with liver disease should be closely monitored when using Daklinza as they are at an increased risk of experiencing harmful side effects. Particularly, in patients with advanced cirrhosis, a careful evaluation is required due to reported cases of liver failure and associated deaths.
- Drug Interactions: Daclatasvir 60 mg may interact with other drugs, especially those metabolized by the CYP3A liver enzyme. Medications that significantly induce or inhibit this enzyme can alter Daclatasvir’s levels in the body, potentially reducing its efficacy or amplifying adverse effects.
- Hepatitis B Reactivation: For patients co-infected with hepatitis B virus (HBV) and HCV, there have been reports of HBV reactivation during or after treatment with HCV direct-acting antivirals without concurrent HBV antiviral therapy. Such reactivation can lead to severe liver issues, including liver failure and even death.
- Pregnancy and Breastfeeding Concerns: The effects of the drug on an unborn baby are not well-known, and it’s unclear whether it can be transferred through breast milk. If a patient becomes pregnant during treatment, it’s important to inform their healthcare provider. Breastfeeding mothers should discuss with their healthcare provider whether to discontinue breastfeeding or discontinue treatment, taking into account the importance of the medication to the mother.
- HIV-1 Co-infection: Patients co-infected with HIV-1 should not use Daclatasvir unless they are also on antiretroviral therapy due to the risk of HIV-1 virus rebound.
- Rare Hereditary Disorders: Individuals with certain rare genetic disorders, such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption, should avoid taking this medication.
- Cardiac Arrhythmias: The use of this drug in combination with sofosbuvir in patients who are on amiodarone is not recommended due to the risk of significant symptomatic slow heart rate.
Interactions with other drugs
Here is a table that includes drugs and their potential interactions with Daklinza (daclatasvir):
| Drug/Drug Class | Example Drugs | Interaction with Daklinza |
| CYP3A Inducers | Rifampin (Rifadin), Phenytoin (Dilantin), Carbamazepine (Tegretol), St. John’s Wort, Phenobarbital (Luminal) | Can lower Daclatasvir’s blood levels, possibly undermining its effectiveness. |
| CYP3A Inhibitors | Ketoconazole (Nizoral), Ritonavir (Norvir), Clarithromycin (Biaxin), Itraconazole (Sporanox), Atazanavir (Reyataz) | Can raise Daclatasvir’s blood levels, potentially increasing the risk of side effects. |
| Amiodarone | Amiodarone (Cordarone, Pacerone) | Co-administration with Daklinza and sofosbuvir can lead to a significant drop in heart rate. This combination is typically avoided unless no other alternatives are present. |
| Antiretroviral Drugs | Tenofovir (Viread), Emtricitabine (Emtriva), Efavirenz (Sustiva), Raltegravir (Isentress), Abacavir (Ziagen) | Daklinza should be used alongside antiretroviral therapy in patients co-infected with HIV-1. Failing to do so can result in increased HIV-1 virus levels. |
| Antacids and H2 Antagonists | Aluminum Hydroxide/Magnesium Hydroxide (Maalox), Calcium Carbonate (Tums), Ranitidine (Zantac), Famotidine (Pepcid) | These can lower the absorption of Daclatasvir, potentially reducing its effectiveness. Daklinza should be taken either 4 hours prior or 2 hours after these medications. |
| Direct-acting Antivirals | Sofosbuvir (Sovaldi), Ledipasvir (Harvoni), Velpatasvir/Sofosbuvir (Epclusa), Elbasvir/Grazoprevir (Zepatier) | This drug is often co-administered with other direct-acting antivirals. The interactions between these drugs and their collective effect on the liver need to be monitored closely. |
| Protease Inhibitors | Boceprevir (Victrelis), Telaprevir (Incivek), Simeprevir (Olysio), Paritaprevir (in Viekira Pak, Technivie) | These drugs can interact with Daclatasvir, potentially reducing its efficacy or raising its side effects. |
Please note that this table is not exhaustive, and other drug interactions may exist. Always consult with a healthcare provider before starting any new medication while taking Daklinza.
Storage
The effectiveness of the tablets can be preserved by keeping them in their original, sealed container until the time comes to take them.
This medicine is best stored at room temperature, with the ideal being around 25°C (77°F). However, it can withstand temporary temperature changes between 15°C and 30°C (59°F to 86°F).
Choose a storage spot for Daklinza 60 mg that is dry and away from direct light to maintain its potency. Avoid damp or bright locations such as bathrooms or near windows. Additionally, the drug should not be stored in overly cold areas like the refrigerator or freezer as it can affect the quality of the medicine.
As a safety measure, the medication should be stored where children and pets cannot reach or see it to prevent any accidental ingestion.
Before you begin using the tablets, make sure to check the expiration date on the container. Do not use the medicine if it has expired. If you have leftover or expired tablets, consult your pharmacist or your local waste disposal company for the proper disposal method.
If you have any uncertainties or questions regarding how to store your medicine, you should always consult your healthcare provider or pharmacist.
Frequently Asked Questions
Does Daklinza cause hair loss?
Hair loss is not a common side effect of this drug. However, everyone is different, and side effects vary among individuals. If you notice any changes in your hair while taking these tablets, report them to your healthcare provider.
What should I do if I accidentally take more than the recommended dose of Daklinza?
If you take more Daclatasvir than you should, contact your healthcare provider immediately or seek emergency medical assistance.
Can Daklinza be used to treat other types of hepatitis?
The drug is specifically used to treat chronic hepatitis C infection and is not approved for the treatment of other types of hepatitis.
Will my hepatitis C become resistant to Daklinza?
There is a risk of the hepatitis C virus developing resistance to Daclatasvir, especially if the medication is not taken as directed. It’s important to take the medication exactly as prescribed by your healthcare provider.
What is Daklinza price?
Although the brand-name drug Daklinza carries a hefty price, an affordable yet equally potent option is available in the form of its generic counterpart, daclatasvir. The daclatasvir price for a quantity of 28 tablets is approximately $540. Consequently, it’s apparent that daclatasvir provides a far more economical solution.
Can I get vaccinated while taking Daklinza?
It’s generally safe to receive vaccines while taking these tablets, but you should always consult your healthcare provider first.
Reviews
Olivia: “Daklinza 60 mg is a good medication overall. I did have some nausea, but it was manageable and my Hep C is now under control.”
David: “This tablet was quite tough for me. The side effects were too severe, leading to a switch in medication.”
Emily: “After a 24-week course of Daklinza, I’m now Hep C free. I experienced minor side effects, but it was well worth it.”
Chris: “These pills helped me battle Hep C effectively. Despite some fatigue, my doctor helped manage the side effects.”
Nora: “Extremely grateful for this generic drug. Side effects were few and far between, and now my Hep C is undetectable.”
Adam: “Daklinza 60 mg tablet did the job, but it wasn’t easy. Fatigue and headaches were the norm, but my Hep C is now under control.”
Zoe: “This drug has been amazing. Minimal side effects and my Hep C is now a thing of the past.”
Brian: “The effectiveness of these tablets is undeniable. I did experience some side effects, but it’s a small price to pay to be Hep C free.”
Harper: “It was a mixed bag for me. It worked in controlling Hep C, but I had to deal with side effects like headaches and fatigue.”
Clara: “I can’t thank Daklinza enough. My latest tests show no trace of Hep C. The side effects were minimal and totally worth it.”
Eric: “The drug worked quite well for me. I had some side effects, but overall it’s a solid medication for Hep C.”
Sophia: “Incredible! This medication has changed my life. After years of dealing with Hep C, I’m finally free. Side effects were mild, and I couldn’t be happier.”
Disclaimer: The information provided in this article is for informational purposes only and should not be taken as medical advice. The content is not intended as a substitute for professional medical diagnosis, advice or treatment. Always consult a doctor before taking any erectile dysfunction medication and discuss any possible risks, side effects, or concerns. Taking medication comes with risks and possible side effects, and individual results may vary. All potential benefits should be weighed against potential risks in consultation with a healthcare professional. The author and publisher of this article shall not be liable for any damages or adverse consequences resulting from the use of or reliance on the information provided herein.